Supply high quality 6-Bromo-2-naphthoic acid CAS 5773-80-8
6-Bromo-2-naphthalene carboxylic acid;
2-Naphthalenecarboxylic acid, 6-bromo-
6-Bromo-2-naphthoic acid CAS:5773-80-8 is used in the preparation of Adapalene, a synthetic aromatic retinoid with specificity for RARβ and RARγ receptors. Adapalene CAS: 106685-40-9 is a topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation.
6-Bromo-2-naphthoic acid CAS:5773-80-8 has a molecular formula of C11H7BrO2 and a molecular weight of 251.08. This 6-bromo-2-naphthoic acid production method involves reacting 6-hydroxy-2-naphthoic acid with ammonia in the presence of sulfite or bisulfite to obtain 6-amino-2-naphthoic acid, subjecting the obtained 6-amino-2-naphthoic acid to a diazotization reaction to obtain a diazotized compound, and subsequently reacting the diazotized compound with copper bromide in the presence of an acid. By means of the present invention, it is possible to produce 6-bromo-2-naphthoic acid with high yield and high purity at low cost.