High quality Ceritinib intermediate CAS 1380575-45-0 in stock
2-Isopropoxy-5-methyl-4-(4-piperidinyl)aniline dihydrochloride ;
5-Methyl-2-(1-methylethoxy)-4- (4-piperidinyl)- benzenamine hydrochloride ;
Ceritinib intermediate CAS 1380575-45-0 appears to be white powder. Ceritinib is an orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.
Ceritinib intermediate CAS 1380575-45-0 has a molecular formula of C15H26Cl2N2O and a molecular weight of 321.29
Ceritinib intermediate CAS 1380575-45-0 could be supplied in commercial size with competitive price.