High quality 1-Hydroxybenzotriazole hydrate CAS 123333-53-9 HOBT hydrate in stock
HOBT hydrate;HOBt H2O;1h-1,2,3-benzotriazol-1-ol hydrate;Benzotriazol-1-ol Hydrate
1-Hydroxybenzotriazole hydrate CAS12333-53-9 is utilized in solid phase peptide synthesis as an additive during amino acid activation and coupling to suppress racemization. It is reported that adding a small amount of HOBt to the Fmoc cleavage solution can suppress aspartimide formation.
1-Hydroxybenzotriazole hydrate CAS12333-53-9 produces activated esters that ensures the condensation of the amino group of protected amino acids.
1-Hydroxybenzotriazole hydrate CAS12333-53-9 is widely used in solid phase peptide synthesis (SPPS), Hydroxybenzotriazole (HOBt) Hydrate is a derivative of benzotriazole. It is a white crystalline powder, (~11.7% wt as the HOBt monohydrate crystal). It is mainly used to suppress the racemization of single-enantiomer chiral molecules and to improve the efficiency of peptide synthesis.