Factory Supply Venetoclax /ABT-199 Intermediate CAS: 1228780-72-0/pharmaceutical Grade

Venetoclax intermediate CAS 1228780-72-0 appears to be white powder. Venetoclax CAS 1257044-40-8 is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia. Venetoclax intermediate CAS 1228780-72-0 has a molecular formula of C19H27ClN2 and a molecular weight of 318.88. Venetoclax intermediate CAS 1228780-72-0 could be supplied in commercial size with competitive price.
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Product Details

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Product Description

Name

Factory Supply Venetoclax /ABT-199 intermediate CAS: 1228780-72-0/pharmaceutical grade

Other name

ABT199 intermediate; 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine;1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine

CAS

1228780-72-0

Applications

ABT199 intermediate

Appearance

White powder

Venetoclax intermediate CAS 1228780-72-0 appears to be white powder. Venetoclax CAS 1257044-40-8 is an orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia. 

Venetoclax intermediate CAS 1228780-72-0 has a molecular formula of C19H27ClN2 and a molecular weight of 318.88.

Venetoclax intermediate CAS 1228780-72-0 could be supplied in commercial size with competitive price.

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