Factory Price Pyrimidine-2-carbonitrile 2-Cyanopyrimidine CAS 14080-23-0 98%

Pyrimidine-2-carbonitrile CAS:14080-23-0 is a protease defined by its high specificity for kinins, which is involved in bone resorption. Cathepsin K's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. Such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. Therefore, inhibitors of Cathepsin K are showing great potential in the treatment of osteoporosis. Pyrimidine-2-carbonitrile CAS:14080-23-0 was identified as a cathepsin K inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. Enzymatic study showed that 2-cyano-Pyrimidine had an IC50 value of 170 nM for inhibition of cathepsin K, elevated activity of which has been linked to the formation of osteoporosis and arthritis. Moreover, Cathepsin K was found to be a lysosomal cysteine protease found in osteoclasts. Pyrimidine-2-carbonitrile CAS:14080-23-0 is heterocyclic pyrimidine derivative with molecular formula (C5H3N3), a off-white crystal powder with high purity (98%min. HPLC assay). Its melting point is only 40-44 cent degree, which should be stored under cool, dry and shadow place to avoid melting in summer.
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Product Details

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Product Description

Name

Pyrimidine-2-carbonitrile 2-Cyanopyrimidine  CAS 14080-23-0 98% with high quality

Other name

2-Pyrimidinecarbonitrile 

pyrimidine-2-carbonitrile

2-cyano-pyrimidine

CAS

14080-23-0

Appearance

white powder 

Purity

98%min.

Applications

Used as Cathepsin K inhibitor for the treatment of osteoperosis

Pyrimidine-2-carbonitrile CAS:14080-23-0 is a protease defined by its high specificity for kinins, which is involved in bone resorption. Cathepsin K's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. Such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. Therefore, inhibitors of Cathepsin K are showing great potential in the treatment of osteoporosis.



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