Disulfiram CAS 97-77-8

Disulfiram CAS 97-77-8 is an organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. It has a role as an EC [aldehyde dehydrogenase (NAD(+))] inhibitor, an angiogenesis inhibitor, an EC (cholinesterase) inhibitor, an EC (carboxylesterase) inhibitor, an EC (DNA topoisomerase) inhibitor, a fungicide, an apoptosis inducer, a NF-kappaB inhibitor and an antineoplastic agent.
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Product Details

Name: Disulfiram (1,840,000)

Other name:

Antabuse (2,270,000)

Antabus (442,000)

Tetraethylthiuram disulfide (38,600)

CAS: 97-77-8

EINECS: 202-607-8

MF: C10H20N2S4          

MW: 296.52

Appearance: Off-white powder

MP: 70-74

Purity: 98%

Package: 1kg, 5kg, 25kg

Applications: API

  Disulfiram CAS 97-77-8 is an alcohol deterrent used as an adjunct to treatment of chronic alcoholism, based upon its ability to cause an aversive reaction when taken with alcohol. Disulfiram has been associated a low rate of with serum aminotransferase elevations during chronic therapy and has been linked to clinical apparent acute liver injury which can be severe and result in fatality.

Disulfiram CAS 97-77-8 is an orally bioavailable carbamoyl derivative and a proteasome inhibitor that is used in the treatment of alcoholism, with potential antineoplastic and chemosensitizing activities. Disulfiram (DSF) may help to treat alcoholism by irreversibly binding to and inhibiting acetaldehyde dehydrogenase, an enzyme that oxidizes the ethanol metabolite acetaldehyde into acetic acid. Inhibition of acetaldehyde dehydrogenase leads to an accumulation of acetaldehyde and produces a variety of very unpleasant symptoms, which together are referred to as the disulfiram-ethanol reaction (DER). In addition, DSF has a strong ability to chelate metals and its antineoplastic activity is highly dependent upon binding to copper (Cu), a metal that selectively accumulates in cancer cells. DSF/Cu generates reactive oxygen species (ROS) and inhibits proteasome activity, leading to an accumulation of ubiquitinated proteins; both of these processes result in induction of apoptosis. Also, DSF/Cu inhibits various cancer-specific pathways, which leads to inhibition of tumor cell growth.

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