High Quality BINOL Derivative: 1,1'-bi-2-naphthol CAS:602-09-5 Wholesale From China

High Quality BINOL Derivative: 1,1'-bi-2-naphthol CAS:602-09-5 Wholesale From China

Chemical name: BINOL; 1,1'-binaphthol; 1,1'-bi-2-naphthol; (1,1'-binaphthalene)-2,2'-diol CAS: 602-09-5 Molecular Formula: C20H14O2 Molecular Weight : 286.32 Appearance : white powder Purity : 99%min. Package : 100g, 500g, 1Kg, 25Kg Applications : Raw material for chiral BINOL or...

Product Details


Chemical name: BINOL; 1,1'-binaphthol; 1,1'-bi-2-naphthol; (1,1'-binaphthalene)-2,2'-diol

CAS: 602-09-5

Molecular Formula: C20H14O2

Molecular Weight: 286.32

Appearance: white powder

Purity: 99%min.

Package: 100g, 500g, 1Kg, 25Kg

Applications:  Raw material for chiral BINOL or BINAP.

 

BINOL has axial chirality and the two enantiomers can be readily separated and are stable toward racemisation, which is a precursor for another chiral ligand called BINAP. The organic synthesis of BINOL is not a challenge as such but the preparation of the individual enantiomers is.

Racemic BINOL can also be produced using iron(III) chloride as an oxidant. The mechanism involves complexation of iron(III) into the hydroxyl, followed by a radical coupling reaction of the naphthol rings initiated by iron(III) reducing into iron(II).

BINOL could be converted to optical pure R-BINOL or S-BINOL through resolution. Currently, producing larger quantity of both enantiomers through resolution is more economic and effective way. Previously reported resolutions include: 1) making a cyclic phosphate of binaphthol, then resolution and subsequent reduction to release the pure binaphthol;  2) using enzymatic hydrolysis of the diester of binaphthol; and  3) forming inclusion complexes with suitable compounds. The use of N-benzylcinchonidinium chlorideto make inclusion complexes was reported by Tanaka and co-workers for obtaining one enantiomer of binaphthol.Using acetonitrileas solvent, in which the inclusion complex has very low solubility, allows for the isolation of both enantiomers with high enantiomeric excess. This simple and efficient procedure represents a much better resolution for 1,1'-bi-2-naphthol.

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  The manufacturer capacity is around 5MTs per month, which is usually available under 1000Kgs from our warehouse. Its package usually 25Kg per drum and could be delivered by air or by sea upon your requirement.



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