6-(Chloromethyl)uracil CAS 18592-13-7 98% with best quality and price
2,4(1H,3H)-Pyrimidinedione, 6-(chloromethyl)-(11,400); 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione(251,000); (Chloromethyl)-2,4(1H,3H)-pyrimidinedione (10,500)
6-(Chloromethyl)uracilCAS:18592-13-7 is suggested to react with DNAnucleotides ,in frozen aqueous solutions via either hydrogen ion or addition to the double bonds of the bases. Methyl hydrogens of TMP are the preferential sites of the attack by H2NCOCH2. radical.
6-(Chloromethyl)uracilCAS:18592-13-7 ,for dCMP the Cl' site on the sugar group is found to be the preferred site of hydrogen ion by H2NCOCH2. while for dGMP and to a lesser extent dAMP attack al the C8 position of the purine ring is found to be competitive with sugar attack.
6-(Chloromethyl)uracilCAS:18592-13-7In general allylic (UCH2.)-C-6 and (UCH2.)-C-5 radicals are found to be poor hydrogen ors and the only reaction pathway found is the addition to double bonds at C6 in thymine and C8 in adenine and guanine. Whereas, the cytosine 5,6 double bond appears to be unreactive towards addition at low temperatures. Some evidence is found for sugar radical addition to the adenine C8 position.