1-Hydroxybenzotriazole Hydrate CAS12333-53-9

1-Hydroxybenzotriazole hydrate CAS12333-53-9 is utilized in solid phase peptide synthesis as an additive during amino acid activation and coupling to suppress racemization.  It is reported that adding a small amount of HOBt to the Fmoc cleavage solution can suppress aspartimide formation. 1-Hydroxybenzotriazole hydrate CAS12333-53-9 produces activated esters that ensures the condensation of the amino group of protected amino acids. 1-Hydroxybenzotriazole hydrate CAS12333-53-9 is widely used in solid phase peptide synthesis (SPPS), Hydroxybenzotriazole (HOBt) Hydrate is a derivative of benzotriazole. It is a white crystalline powder, (~11.7% wt as the HOBt monohydrate crystal). It is mainly used to suppress the racemization of single-enantiomer chiral molecules and to improve the efficiency of peptide synthesis. 1-Hydroxybenzotriazole hydrate CAS:123333-53-9 could be supplied in commercial size with competitive price.
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Product Details

Name: 1-Hydroxybenzotriazole hydrate

Other name: 

HOBT hydrate

HOBt H2O

1H-1,2,3-Benzotriazole, 1-hydroxy-

1H-Benzotriazol-1-ol

 

CAS:123333-53-9

EINECS:602-929-2

MF:C6H5N3O 

MW:135.13

Appearance:White crystal powder

MP:155-160℃

Purity: 98%min. 

Package: 25g, 100g, 1Kg, bulk package

Applications: Organic intermediate

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