1-Hydroxybenzotriazole Hydrate CAS12333-53-9

1-Hydroxybenzotriazole Hydrate CAS12333-53-9

1-Hydroxybenzotriazole hydrate CAS12333-53-9 is utilized in solid phase peptide synthesis as an additive during amino acid activation and coupling to suppress racemization. It is reported that adding a small amount of HOBt to the Fmoc cleavage solution can suppress aspartimide formation. 1-Hydroxybenzotriazole hydrate CAS12333-53-9 produces activated esters that ensures the condensation of the amino group of protected amino acids. 1-Hydroxybenzotriazole hydrate CAS12333-53-9 is widely used in solid phase peptide synthesis (SPPS), Hydroxybenzotriazole (HOBt) Hydrate is a derivative of benzotriazole. It is a white crystalline powder, (~11.7% wt as the HOBt monohydrate crystal). It is mainly used to suppress the racemization of single-enantiomer chiral molecules and to improve the efficiency of peptide synthesis. 1-Hydroxybenzotriazole hydrate CAS:123333-53-9 could be supplied in commercial size with competitive price.

Chat Now