Bacteria use the CRISPR / Cas system to escape the host immune system

- Nov 02, 2017 -

Clustered regular interspaced short palindromic transition (CRISPR) is a gene system used by bacteria to resist viruses. In a new study, studies from Emory University in the United States Personnel found CRISPR involved in assisting some bacteria to escape the mammalian immune system.

Bacteria are self-protected using CRISPR, and its function was initially discovered by dairy industry researchers who tried to prevent phage (infected bacteria) from destroying bacterial cultures used to make cheese and yogurt. Bacteria will come from small phage Fragments of DNA into their own CRISPR region, and through the intake of phage DNA information obtained to prevent the invasion of these viruses.

Now, in this new study, the researchers confirmed that the new killer Francisella novicida (F. novicida) needed to be associated with a bacterium that causes rabbit fever and another bacteriophage that causes meningitis CRISPR system to maintain infectivity. Bacteria grown in mammalian cells F. novicida uses a portion of the CRISPR system to shut down a bacterial gene to escape their host from the detection and destruction of this gene trigger.